The Panel also evaluated the data on long-term toxicity and carcinogenicity for chromium(III). The Panel concluded that in very large amounts, certain trivalent chromium compounds are cytotoxic and have been shown to cause chromosomal damage.
The Panel also evaluated new in vitro and in vivo studies on the genotoxicity of chromium(III) compounds which were not covered by previous evaluations. The results of other genotoxicity studies are conflicting. The results of in vitro bacterial mutagenicity assays have been consistently negative. The Panel concluded that following oral administration, trivalent chromium is poorly absorbed. The Panel on Food Additives and Nutrient Sources added to Food delivers a scientific opinion re-evaluating the safety of chromium(III) as a nutrient added to foods for particular nutritional uses (PARNUTS) and foods intended for the general population (including food supplements). Competent organisations in Member States.
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